ProBiS Home Page ProBiS Home Page Protein Binding Sites Detection As of Nov 30, 2013 your protein is compared with 37643 structures
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ProBiS Algorithm

ProBiS program aligns and superimposes complete protein surfaces, surface motifs, or protein binding sites. It enables pairwise alignments as well as fast database searches for similar proteins or binding sites. The program can find similar binding sites even in proteins with different folds. ProBiS program is parallel, for single or multiple CPU platforms, and implements the latest ProBiS algorithm (Parallel-ProBiS algorithm).

Download Latest Version

Latest Version (2012/08/31):   ProBiS-2.4.2 Source Code      ProBiS-2.4.2 Documentation (Updated on Nov/12/2012)

Old versions are here.

Installation Instructions

For installation of the ProBiS source code on Ubuntu (or similar system) do the following:
  • Unzip the distribution. A directory is created, in which there is the source code of ProBiS algorithm. Change to this directory after the unpacking is complete.
    $ unzip probis-{version_number}.zip
    $ cd probis-{version_number}
  • Compile ProBiS source code into executable program.
    $ make probis
  • When compiled, type 'probis' to start.
    $ ./probis

Required Libraries

ProBiS requires Open MPI library, GNU scientific library and GNU C++ compiler. Installation of these libraries for Ubuntu is easy:
$ sudo apt-get install openmpi-bin libopenmpi-dev libgsl0-dev g++


ProBiS in Brief
Query structure is shown in Jmol colored by the degrees of structural conservation.
Structurally conserved residues (red) correspond with the GDP binding site.
Local pairwise structural alignment of two differently folded proteins.
Similar proteins are ranked by Z-Scores. A red star indicates different Protein Family (Pfam) than that of query.
Local pairwise structural alignment is presented as a table of residue-residue correspondences.
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ProBiS is developed at the National Institute of Chemistry, Ljubljana, Slovenia