ProBiS Server

As of Jul 31, 2015 your protein is compared with 42270 structures

HELP

Alert: For ProBiS to work, please enable JavaScript in your browser! Click here for instructions. Reload this page.

Introduction

There are two ProBiS web pages out there: ProBiS at http://probis.cmm.ki.si maintained at the National Institute of Chemistry, Slovenia, and ProBiS-CHARMMing at https://probis.nih.gov situated at the National Institutes of Health, USA. Why is that? ProBiS-CHARMMing has additional functions only available from inside NIH: it enables energy minimization of predicted protein-ligand complexes and their interaction energy calculation.

Pages

Download

Help

Most Recent Citation

Konc, J., Miller, B. T., Stular, T., Lesnik, S., Woodcock, H. L., Brooks, B. R., and Janezic, D. ProBiS-CHARMMing: Web Interface for Prediction and Optimization of Ligands in Protein Binding Sites. J. Chem. Inf. Model., 2015, 55, 2308-2314.

Related Citations

Konc,J. and Janezic,D. ProBiS–ligands: a web server for prediction of ligands by examination of protein binding sites. Nucleic Acids Res., 2014, 42, W215-W220.
Konc,J. and Janezic,D. ProBiS–2012: web server and web services for detection of structurally similar binding sites in proteins. Nucleic Acids Res., 2012, 40, W214-W221.
Konc,J., Cesnik,T., Trykowska Konc,J., Penca,M., Janezic,D. ProBiS-Database: Precalculated Binding Site Similarities and Local Pairwise Alignments of PDB Structures. J. Chem. Inf. Model., 2012, 52, 604-612.
Konc,J. and Janezic,D. ProBiS algorithm for detection of structurally similar protein binding sites by local structural alignment. Bioinformatics, 2010, 26, 1160-1168.
Konc,J. and Janezic,D. ProBiS: a web server for detection of structurally similar protein binding sites. Nucleic Acids Res., 2010, 38, W436-W440.
Konc,J. and Janezic,D. Protein-protein binding-sites prediction by protein surface structure conservation. J. Chem. Inf. Model., 2007, 47, 940-944.
Konc,J. and Janezic,D. An improved branch and bound algorithm for the maximum clique problem. MATCH Commun. Math. Comput. Chem., 2007, 58, 569-590.

Video Tutorial

Contact

Scientific : konc [at] cmm [dot] ki [dot] si

Release Notes

Mar 14 2016: Added color legend for superimposed proteins
Feb 23 2016: It is now possible to download the predicted ligands as text file
Feb 1 2016: Fixed clustering of protein and nucleic ligands, consequently there are much more in the output

HHS Responsible Disclosure

Policies : Privacy Policy